Endocrine Abstracts

Background and aim: Gestational Diabetes Mellitus (GDM) is often diagnosed at 24-28 weeks of pregnancy when the fetal phenotype is already altered. We aimed to develop a machine learning model based on clinical variables, lifestyle features and genetic markers for GDM prediction in the first trimester of pregnancy based on the 2013 World Health Organization (WHO) criteria.Methods: Using multivariable logistic regression analysis, different models to pred...

Background and aims: Current glycaemic treatment targets for women with gestational diabetes (GDM) are controversial. The aim of the study was to compare the effect of different intensities of glycaemic control in pregnant women with GDM on perinatal outcomes.Materials and methods: Pregnant women in the 8th to 31st week of gestation were randomly assigned to 2 groups per target glycaemic levels: GDM1 (very tight glycaemic targets, fasting blood glucose (...

Background and Aims: The gut microbiome has been shown to differ between healthy individuals and those with diabetes and even in women with gestational diabetes mellitus (GDM). This raises the question of its role in postprandial glycemic response (PPGR). We aimed to evaluate the impact of microbiome features in PPGR in women with GDM and healthy pregnant women.Methods: We obtained stool samples for 96 pregnant women (65 GDM, 31 control), previously recr...